Hydrochloric Acid → 2-acetamido-N-tert-butyl-2-(2-(1,2,3,4-tetrahydroisoquinolin-3-yl)ethyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)hexanamide

HRID 579536ノート

反応式

HRID 579536 の反応式
[C:1]([NH:4][C:5]([C:38](=[O:44])[NH:39][C:40]([CH3:43])([CH3:42])[CH3:41])([CH2:25][CH2:26][CH2:27][CH2:28][B:29]1[O:33][C:32]([CH3:35])([CH3:34])[C:31]([CH3:37])([CH3:36])[O:30]1)[CH2:6][CH2:7][CH:8]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][N:9]1C(OC(C)(C)C)=O)(=[O:3])[CH3:2].Cl>C(OCC)(=O)C>[C:1]([NH:4][C:5]([CH2:6][CH2:7][CH:8]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][NH:9]1)([CH2:25][CH2:26][CH2:27][CH2:28][B:29]1[O:30][C:31]([CH3:36])([CH3:37])[C:32]([CH3:34])([CH3:35])[O:33]1)[C:38]([NH:39][C:40]([CH3:41])([CH3:42])[CH3:43])=[O:44])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 66833409tert-butyl 3-(3-acetamido-3-(tert-butylcarbamoyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)heptyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

生成物 1

HCID 668337032-acetamido-N-tert-butyl-2-(2-(1,2,3,4-tetrahydroisoquinolin-3-yl)ethyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)hexanamide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

A solution of tert-butyl 3-(3-acetamido-3-(tert-butylcarbamoyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)heptyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate in ethyl acetate was treated with a solution of HCl (g) in ethyl acetate (approximately 2 M). After stirring for 30 min the reaction was concentrated to dryness and the crude hydrochloride product was used without further purification.

後処理

  1. concentrationwas concentrated to dryness
  2. customthe crude hydrochloride product was used without further purification

出典と根拠

ORDレコード
ord-e1cc7bd7acb54984902755d39568f990
出典データセット
uspto-grants-2015_05
特許番号
US09040703B2

反応ノート

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