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Ammonia → 6-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 4H-pyran-4-one | HCID 7968 | — |
| 反応物 | 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone hydrochloride | HCID 12805005 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone | HCID 19794225 | — |
反応手順
A stirred mixture of 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone hydrochloride (1.5 g), 4H-pyran-4-one (0.7 g), and water (20 ml), was heated under reflux for 41/2 hours. The resultant solid was dissolved in the minimum of hot water and the solution was neutralised with ammonia to give the crude product. Recrystallisation from water gave the title compound, 0.73 g, m.p. 270°-272° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05246928 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-485e041677a3458f8860e1c73bcd36fb |
| 出典メモ | uspto-grants-1993_09 |