Ammonia → 6-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone

HRID 5797

反応式

HRID 5797 の反応式
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH2:10][CH2:11][C:12](=[O:15])[NH:13][N:14]=2)=[CH:5][CH:4]=1.O1[CH:21]=[CH:20][C:19](=[O:22])[CH:18]=[CH:17]1.N>O>[O:22]=[C:19]1[CH:20]=[CH:21][N:2]([C:3]2[CH:8]=[CH:7][C:6]([C:9]3[CH2:10][CH2:11][C:12](=[O:15])[NH:13][N:14]=3)=[CH:5][CH:4]=2)[CH:17]=[CH:18]1

参加物

5

反応物 3

HCID 222AmmoniaHCID 79684H-pyran-4-oneHCID 128050056-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone hydrochloride

生成物 1

HCID 197942256-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A stirred mixture of 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone hydrochloride (1.5 g), 4H-pyran-4-one (0.7 g), and water (20 ml), was heated under reflux for 41/2 hours. The resultant solid was dissolved in the minimum of hot water and the solution was neutralised with ammonia to give the crude product. Recrystallisation from water gave the title compound, 0.73 g, m.p. 270°-272° C.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 41/2 hours
  3. customto give the crude product
  4. customRecrystallisation from water

出典と根拠

ORDレコード
ord-485e041677a3458f8860e1c73bcd36fb
出典データセット
uspto-grants-1993_09
特許番号
US05246928

関連ノート

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