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4-Aminobenzoic Acid → p-((1-Oxoallyl)amino)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminobenzoic Acid | HCID 978 | — |
| 反応物 | Acryloyl chloride | HCID 13140 | — |
| 反応物 | Aminobenzoic acid hydrochloride | HCID 12209225 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | p-((1-Oxoallyl)amino)benzoic acid | HCID 84866 | 78.8% |
反応手順
0.66 g (7.3 mmoles) of acryloyl chloride was added to a solution of 2 g (14.3 mmoles) of p-aminobenzoic acid in 40 mL tetrahydrofuran (THF). A white precipitate consisting of p-aminobenzoic acid hydrochloride formed. The suspension was filtered and the filtrate was dried by vacuum evaporation to yield 1.1 g p-acrylamidobenzoic acid (reaction shown in FIG. 16a).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04749647 |
| 出典データセット | uspto-grants-1988_06 |
| ORD ID | ord-bee312e1396e42e4aee42cf412906e72 |
| 出典メモ | uspto-grants-1988_06 |