2-Methylquinoline → 2-[(E)-2-(3-nitrophenyl)vinyl]quinoline

HRID 579729ノート

反応式

HRID 579729 の反応式
C(OC(=O)C)(=O)C.[N:8]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][C:9]=1[CH3:10].[N+:19]([C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH:25]=O)([O-:21])=[O:20]>O>[N+:19]([C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)/[CH:25]=[CH:10]/[C:9]1[CH:11]=[CH:12][C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:8]=1)([O-:21])=[O:20]

参加物

5

反応物 3

HCID 70602-MethylquinolineHCID 74493-NitrobenzaldehydeHCID 7918Acetic Anhydride

生成物 1

HCID 53766172-[(E)-2-(3-nitrophenyl)vinyl]quinoline収率 88%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
160 °C

実験手順

To 3.1 g of acetic anhydride, 7.2 g of quinaldine and 7.6 g of m-nitrobenzaldehyde were added and the resulting mixture was stirred under nitrogen atmosphere at 160° C. for 4 hours. After completion of the reaction, water was added to the reaction mixture and the resulting solid was collected by filtration and dried. Recrystallization from toluene gave 12.1 g (yield: 88%) of the captioned compound as an yellow powder.

後処理

  1. additionwas added to the reaction mixture
  2. filtrationthe resulting solid was collected by filtration
  3. customdried
  4. customRecrystallization from toluene

出典と根拠

ORDレコード
ord-6805216384184842b8c78adcbe30a236
出典データセット
uspto-grants-1988_06
特許番号
US04749701

反応ノート

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