4-Aminobenzonitrile → 7-Acetoxy-4-(4-cyanoanilino)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

HRID 579747ノート

反応式

HRID 579747 の反応式
[C:1]([O:4][CH:5]1[C:9]2[N:10]=[CH:11][N:12]=[C:13](Cl)[C:8]=2[CH2:7][CH2:6]1)(=[O:3])[CH3:2].[NH2:15][C:16]1[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=1>C(O)C>[C:1]([O:4][CH:5]1[C:9]2[N:10]=[CH:11][N:12]=[C:13]([NH:15][C:16]3[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=3)[C:8]=2[CH2:7][CH2:6]1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 133964-AminobenzonitrileHCID 199689354-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-7-yl acetate

生成物 1

HCID 139132267-Acetoxy-4-(4-cyanoanilino)-6,7-dihydro-5H-cyclopenta[d]pyrimidine収率 55.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

39.3 g of 7-acetoxy-4-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine [prepared as described in step (b) above] and 24 g of p-aminobenzonitrile were dissolved in 180 ml of ethanol, and the solution was heated under reflux for 1.5 hours. At the end of this time, the solvent was evaporated off under reduced pressure, and the resulting residue was washed with a 1:1 by volume mixture of ethanol and toluene, to give 30 g of the title compound as pale grayish crystals, melting at 215°-217° C.

後処理

  1. temperaturethe solution was heated
  2. temperatureunder reflux for 1.5 hours
  3. customAt the end of this time, the solvent was evaporated off under reduced pressure
  4. washthe resulting residue was washed with a 1:1 by volume mixture of ethanol and toluene

出典と根拠

ORDレコード
ord-064491002d1040118ff9c94364c8cb47
出典データセット
uspto-grants-1988_06
特許番号
US04749704

反応ノート

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