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Potassium Iodide → 1-(2-(Benzyloxy)-4-fluorophenyl)ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Benzyl Chloride | HCID 7503 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4'-Fluoro-2'-hydroxyacetophenone | HCID 2737326 | — |
| 反応物 | N-[(1-acetyl-4-piperidinyl)methyl]-N'-(2-fluorophenyl)thiourea | HCID 21241609 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 2,3-Dihydro-1,4-benzodioxin-6-yl isothiocyanate | HCID 2776173 | — |
| 生成物 | 1-(2-(Benzyloxy)-4-fluorophenyl)ethanone | HCID 21241577 | 58% |
反応手順
A mixture of 13 parts of 1-(4-fluoro-2-hydroxyphenyl)ethanone, 14.9 parts of (chloromethyl)benzene, 16.4 parts of potassium carbonate, 0.1 parts of potassium iodide and 120 parts of 2-propanone was stirred overnight at reflux temperature. The reaction mixture was evaporated. The reaction mixture was poured into water. The product was extracted three times with trichloromethane. The combined extracts were dried, filtered and evaporated. The residue was crystallized from a mixture of 2-propanol and water. The product was filtered off and dried, yielding 11 parts (58%) of 1-[4-fluoro-2-(phenylmethoxy)phenyl]ethanone (intermediate 76).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04749702 |
| 出典データセット | uspto-grants-1988_06 |
| ORD ID | ord-999acce87e7e48318b5901a2eb848d87 |
| 出典メモ | uspto-grants-1988_06 |