Methanol → AC-Pro-ome

関与物質

反応条件

反応手順

A 70 ml stainless steel high pressure reactor having a Pyrex glass liner and a magnetic stir bar was charged with 5 mL of tetrahydrofuran, 0.5 mmol of n-pentadecane internal standard, 0.5 mmol of CH3OH, 10.0 mg of Co2 (CO)6 (PPh3)2, and 55.0 mg of N-acetyl-2-pyrroline. The reactor was pressurized with 1320 psi of CO and 300 psi of H2 at room temperature, and the reaction mixture was stirred at 100° C. for 21.75 hours. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography, and the analysis indicated 76.6% conversion of N-acetyl-2-pyrroline and 4.1% yield of N-acetylproline methyl ester.

情報源と証拠