Benzaldehyde → 1-Propanamine, 2-methyl-N-(phenylmethylene)-

HRID 579838ノート

反応式

HRID 579838 の反応式
[CH2:1]([NH2:5])[CH:2]([CH3:4])[CH3:3].[CH:6](=O)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C1C=CC=CC=1>[CH:6](=[N:5][CH2:1][CH:2]([CH3:4])[CH3:3])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 240BenzaldehydeHCID 6558Isobutylamine

生成物 1

HCID 118050671-Propanamine, 2-methyl-N-(phenylmethylene)-収率 89.4%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To a stirred solution of isobutylamine (49.7 ml, 500 mmol) in dry benzene (50 ml) was added benzaldehyde (50.8 ml, 500 mmol) over a period of 20 minutes. After three hours, the water layer was separated and the stirring of the benzene solution continued overnight. Again the separated water layer was discarded. The benzene layer after further dilution with dry benzene (150 ml) was dried over a minimum amount of magnesium sulfate. After concentrating the dried benzene solution, the residue was distilled in vacuo, yielding 72.1 g of compound, boiling point 46°-48° C. at 0.1 mm of Hg.

後処理

  1. customthe water layer was separated
  2. waitcontinued overnight
  3. dry with materialThe benzene layer after further dilution with dry benzene (150 ml) was dried over a minimum amount of magnesium sulfate
  4. concentrationAfter concentrating the dried benzene solution
  5. distillationthe residue was distilled in vacuo

出典と根拠

ORDレコード
ord-ee6bd03996a4456c88fc4dbebd772638
出典データセット
uspto-grants-1988_06
特許番号
US04749792

反応ノート

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