HCID 20136772、化合物 → 2-amino-5-isopropylbenzotrifluoride

HRID 579856ノート

反応式

HRID 579856 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:12])[CH3:11])=[CH:6][C:5]=1[C:13]([F:16])([F:15])[F:14])([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:12])[CH3:11])=[CH:6][C:5]=1[C:13]([F:14])([F:15])[F:16]

参加物

4

反応物 1

HCID 20136772HCID 20136772、化合物

生成物 1

HCID 27752232-amino-5-isopropylbenzotrifluoride収率 97.4%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

330 g of 2-nitro-5-isopropylbenzotrifluoride in 1,200 ml of methanol are initially introduced into a hydrogenation apparatus, and 30 g of Raney nickel are added. After the system has been flushed with hydrogen, a hydrogenation is carried out at 25°-45° C. under a pressure of 30 bar of hydrogen. After the hydrogen absorption is complete, the solution is filtered to separate off the catalyst. After the solvent has been distilled off, the product is distilled. 280 g of 2-amino-5-isopropylbenzotrifluoride (boiling point: 95°-8° C./18 mbar, nD20 : 1.4810) are obtained.

後処理

  1. additionare added
  2. customAfter the system has been flushed with hydrogen
  3. customis carried out at 25°-45° C. under a pressure of 30 bar of hydrogen
  4. customAfter the hydrogen absorption
  5. filtrationthe solution is filtered
  6. customto separate off the catalyst
  7. distillationAfter the solvent has been distilled off
  8. distillationthe product is distilled

出典と根拠

ORDレコード
ord-dfd5552c4a3344a79a6874cd30b81d7c
出典データセット
uspto-grants-1988_06
特許番号
US04749813

反応ノート

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