Acetic Acid → N-Acetyl-2,6-xylidine

HRID 579968

反応式

HRID 579968 の反応式
[NH2:1][C:2]1[C:3]([CH3:9])=[CH:4][CH:5]=[CH:6][C:7]=1[CH3:8].[C:10](OC(=O)C)(=[O:12])[CH3:11].C(O)(=O)C>O>[C:10]([NH:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:9])(=[O:12])[CH3:11]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 68962,6-DimethylanilineHCID 7918Acetic Anhydride

生成物 1

HCID 16616N-Acetyl-2,6-xylidine収率 92.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 25 ml of 2,6-xylidine (0.20 mole) was added slowly a mixture of 25 ml of acetic anhydride (0.26 mole) and 25 ml of acetic acid (0.44 mole) under stirring at room temperature. The mixture was stirred for 30 minutes at room temperature and, then, diluted with water. The crystalline precipitate was collected by filtration to give 30.1 g (91%) of the title compound (m.p. 182°-184° C.; colorless needles).

後処理

  1. stirringThe mixture was stirred for 30 minutes at room temperature
  2. filtrationThe crystalline precipitate was collected by filtration

出典と根拠

ORDレコード
ord-65932ea602734fb29d525f9b6ee3ee14
出典データセット
uspto-grants-1988_06
特許番号
US04751232

関連ノート

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