Sulfuric Acid → 3-Amino-2,4-dimethylphenol

HRID 579972

反応式

HRID 579972 の反応式
C([NH:4][C:5]1[C:6]([CH3:13])=[C:7]([OH:12])[CH:8]=[CH:9][C:10]=1[CH3:11])(=O)C.S(=O)(=O)(O)O>C(O)C>[NH2:4][C:5]1[C:6]([CH3:13])=[C:7]([OH:12])[CH:8]=[CH:9][C:10]=1[CH3:11]

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 10419764N-(3-Hydroxy-2,6-dimethylphenyl)acetamide

生成物 1

HCID 141306083-Amino-2,4-dimethylphenol収率 69.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 10 g of 3-acetamido-2,4-dimethylphenol (55.9 mmol), 250 ml of concentrated sulfuric acid and 200 ml of ethanol was refluxed for 30 minutes and, then, concentrated under reduced pressure. The residue was dissolved in water and the solution was made alkaline with ammonia water and extracted with ether. The ether layer was washed with a saturated aqueous solution of sodium chloride, dried over magnesium sulfate (dehydration) and concentrated under reduced pressure. The residue was recrystallized from ethanolhexane to give 5.3 g (69%) of the title compound as colorless plates, m.p. 177°-179° C.

後処理

  1. temperaturewas refluxed for 30 minutes
  2. concentrationconcentrated under reduced pressure
  3. dissolutionThe residue was dissolved in water
  4. extractionextracted with ether
  5. washThe ether layer was washed with a saturated aqueous solution of sodium chloride
  6. dry with materialdried over magnesium sulfate (dehydration)
  7. concentrationconcentrated under reduced pressure
  8. customThe residue was recrystallized from ethanolhexane

出典と根拠

ORDレコード
ord-0564bda8e7404383b919e8d4ec3a662c
出典データセット
uspto-grants-1988_06
特許番号
US04751232

関連ノート

読み込み中…