Methyl 2-(3-amino-4-hydroxyphenyl)acetate → HCID 14180325、化合物

HRID 580242

反応式

HRID 580242 の反応式
[CH3:1][O:2][C:3]1[C:11]([CH3:12])=[C:10]([CH3:13])[C:9]([O:14][CH3:15])=[C:8]([CH3:16])[C:4]=1[C:5]([OH:7])=O.[NH2:17][C:18]1[CH:19]=[C:20]([CH2:25][C:26]([O:28][CH3:29])=[O:27])[CH:21]=[CH:22][C:23]=1[OH:24]>>[OH:24][C:23]1[CH:22]=[CH:21][C:20]([CH2:25][C:26]([O:28][CH3:29])=[O:27])=[CH:19][C:18]=1[NH:17][C:5](=[O:7])[C:4]1[C:8]([CH3:16])=[C:9]([O:14][CH3:15])[C:10]([CH3:13])=[C:11]([CH3:12])[C:3]=1[O:2][CH3:1]

参加物

3

反応物 2

HCID 1475136Methyl 2-(3-amino-4-hydroxyphenyl)acetateHCID 27520352,5-Dimethoxy-3,4,6-trimethylbenzoic acid

生成物 1

HCID 14180325HCID 14180325、化合物

実験手順

2,5-Dimethoxy-3,4,6-trimethylbenzoic acid (m.p. 98°-100° C.) was reacted with methyl 3-amino-4-hydroxyphenylacetate to give methyl 4-hydroxy-3-(2,5-dimethoxy-3,4,6-trimethylbenzoylamino)phenylacetate [m.p. 159°-160° C., δ 2.14 (3H), 2.20 (3H), 2.32 (3H), 3.48 (2H), 3.65 (6H), 3.70 (3H), 7.02 (3H), 8.30 (1H), 8.87 (1H)] (11.0 g, 28.4 mmol), which was dehydrated with phosphorus oxychloride (13.1 g) to give methyl 2-[6-(2,5-dimethoxy-3,4,6-trimethylphenyl)benzoxazol-6yl]acetate m.p. 68°-69° C., δ 2.22 (3H), 2.27 (3H), 3.58 (3H), 3.70 (3H), 3.72 (3H), 3.76 (2H), 7.32 (1H), 7.55 (1H), 7.76 (1H)] .

出典と根拠

ORDレコード
ord-82ecaa7ccfb9439a9b68aae7b7a6a805
出典データセット
uspto-grants-1988_06
特許番号
US04751303

関連ノート

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