Methyl 4-bromo-1-methyl-1H-pyrazole-5-carboxylate → (4-bromo-1-methyl-1H-pyrazol-5-yl)methanol

Methyl 4-bromo-1-methyl-1H-pyrazole-5-carboxylate (2 g, 9.13 mmol) in DCM (40 mL) was cooled to −78° C. Diisobutylaluminum hydride (36.5 mL, 36.5 mmol) in DCM was added, and the reaction mixture was stirred for 2 hours at the same temperature. The reaction mixture was subsequently quenched with aqueous saturated sodium potassium tartrate and was transferred to a reparatory funnel, where it was washed with water and brine, dried over Na2SO4, and concentrated to give the title compound as a white solid (0.76 g, 44%).

1. customThe reaction mixture was subsequently quenched with aqueous saturated sodium potassium tartrate
2. customwas transferred to a reparatory funnel
3. washwhere it was washed with water and brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated

ORDレコード

ord-97d9fef71a1c42feaeba9123a32dd627

出典データセット

uspto-grants-2016_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09434743B2