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Methanesulfonyl chloride → N-(5-bromo-6-methylpyridin-2-yl)methanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2-Pyridinamine, 5-bromo-6-methyl- | HCID 170678 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(5-bromo-6-methylpyridin-2-yl)methanesulfonamide | HCID 79049128 | — |
反応手順
To a mixture of 5-bromo-6-methylpyridin-2-amine (0.3 g, 1.604 mmol) and N-ethyl-N-isopropylpropan-2-amine (0.559 mL, 3.21 mmol) in DCM (10 mL) was added methanesulfonyl chloride (0.137 mL, 1.764 mmol) at 0° C. The reaction mixture was stirred at room temperature for 48 hours and was subsequently concentrated in vacuo to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434743B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-eff90a1b5e1d49ba85eea4a95d9dbafd |
| 出典メモ | uspto-grants-2016_09 |