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Potassium Carbonate → 2-(5-bromo-3-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Bromoacetamide | HCID 69632 | — |
| 反応物 | 1-Methyl-5-bromouracil | HCID 73276 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 2-(5-bromo-3-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)acetamide | HCID 89781766 | — |
反応手順
A mixture of 5-bromo-1-methylpyrimidine-2,4(1H,3H)-dione (200 mg, 0.976 mmol), 2-bromoacetamide (162 mg, 1.171 mmol) and K2CO3 (162 mg, 1.171 mmol) in DMSO (4 mL) was stirred at room temperature for 4 hours. The reaction mixture was subsequently filtered and purified via preparative HPLC, eluting with a gradient of 1-40% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA) to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434743B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-55ff6c7d81534e98b295d92b9e624b09 |
| 出典メモ | uspto-grants-2016_09 |