Isatoic Anhydride → 2-Amino-N-[4-(1H-imidazol-1-yl)butyl]benzamide

HRID 580464ノート

反応式

HRID 580464 の反応式
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)[O:4][C:2]2=O.[N:13]1([CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])[CH:17]=[CH:16][N:15]=[CH:14]1>C(O)C>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]([NH:22][CH2:21][CH2:20][CH2:19][CH2:18][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1)=[O:4]

参加物

4

反応物 2

HCID 8359Isatoic AnhydrideHCID 43794804-(1H-imidazol-1-yl)butan-1-amine

生成物 1

HCID 139527342-Amino-N-[4-(1H-imidazol-1-yl)butyl]benzamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 1.63 g of isatoic anhydride, 1.39 g of 1H-imidazole-1-butanamine and 25 ml of ethanol was stirred at room temperature for 22 hours. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate and cooled. The desired product was isolated by filtration, mp 91°14 93° C.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. temperaturecooled

出典と根拠

ORDレコード
ord-a2664955ec9f4ae7943c5f76078d3435
出典データセット
uspto-grants-1988_06
特許番号
US04753944

反応ノート

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