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Pyridine → N-(7-methoxy-1,8-naphthyridin2-yl)-3-acetoxybenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 3-(Chlorocarbonyl)phenyl acetate | HCID 12998558 | — |
| 反応物 | 7-methoxy-1,8-Naphthyridin-2-amine | HCID 21793027 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-(7-methoxy-1,8-naphthyridin2-yl)-3-acetoxybenzamide | HCID 13983395 | 78.6% |
反応手順
The procedure is similar to that described in Example 3, but starting with 2-amino-7-methoxynaphthyridine (3.5 g), 3-acetoxybenzoyl chloride (4.4 g) and anhydrous pyridine (40 cc). The reaction mixture is poured into water (400 cc) and the precipitate obtained is separated by filtration and then washed with water (6×100 cc) and dried in the air. On recrystallization from ethanol (140 cc) of the product thereby obtained, N-(7-methoxy-1,8-naphthyridin2-yl)-3-acetoxybenzamide (5.3 g), m.p. 172° C., is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04753941 |
| 出典データセット | uspto-grants-1988_06 |
| ORD ID | ord-2e02604d1e1447bfb7a6e3d9f54c6d2c |
| 出典メモ | uspto-grants-1988_06 |