3-[(Ethoxycarbonyl)amino]benzoic acid → HCID 13983397、化合物
反応式
[CH2:1]([O:3][C:4]([NH:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][CH:15]=1)[C:10]([OH:12])=O)=[O:5])[CH3:2].[NH2:16][C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[N:20][C:21]([O:27][CH3:28])=[CH:22][CH:23]=2)[N:18]=1>O>[CH3:28][O:27][C:21]1[N:20]=[C:19]2[C:24]([CH:25]=[CH:26][C:17]([NH:16][C:10](=[O:12])[C:9]3[CH:13]=[CH:14][CH:15]=[C:7]([NH:6][C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:8]=3)=[N:18]2)=[CH:23][CH:22]=1参加物
4
実験手順
The procedure is similar to that described in Example 2, but starting with 3-ethoxycarbonylaminobenzoic acid (10 g), N,N'-carbonyldiimidazole (7.6 g) and 2-amino-7-methoxy-1,8-naphthyridine (5.95 g). The reaction mixture is then poured into water (1000 cc) and the precipitate formed is separated by filtration, washed with water (10 cc) and dried in the air. On recrystallization in ethyl acetate (100 cc) of the product thereby obtained, N-(7-methoxy-1,8-naphthyridin-2-yl)-3-ethoxycarbonylaminobenzamide (7.3 g), m.p. 120° C., is obtained.