関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl bromoacetate | HCID 60984 | — |
| 反応物 | 5-Bromo-2-hydroxypyridine | HCID 599528 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | methyl 2-(5-bromo-2-oxopyridin-1(2H)-yl)acetate | HCID 28834262 | — |
反応手順
To solution of 5-bromopyridin-2(1H)-one (2.5 g, 14.37 mmol) and methyl 2-bromoacetate (2.418 g, 15.81 mmol) in DMSO (12 mL) was added K2CO3 (2.383 g, 17.24 mmol). The mixture was stirred at 60° C. for 4 hours, filtered, and purified via preparative HPLC, eluting with a gradient of 10-90% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA) to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09434743B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-8a9a13226ab74f98ba60f664d65d6a8f |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
