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7-Chloro-1,8-naphthyridin-2-amine → HCID 13983407、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 7-Chloro-1,8-naphthyridin-2-amine | HCID 85199 | — |
| 反応物 | 4-Thiazolecarboxylic acid | HCID 304271 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 13983407 | HCID 13983407 | 77.2% |
反応手順
The procedure is similar to that described in Example 2, but starting with 4-thiazolecarboxylic acid (4.8 g), N,N'-carbonyldiimidazole (7.5 g) and 2-amino-7-chloro-1,8-naphthyridine (4.8 g). The product obtained by precipitation in water is purified by recrystallization in dimethylformamide (350 cc). N-(7-Chloro-1,8-naphthyridin-2-yl)-4-thiazolecarboxamide (6 g), m.p. 325° C., is thereby obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04753941 |
| 出典データセット | uspto-grants-1988_06 |
| ORD ID | ord-f0e5d4ae00d04eab8b097595cd343e10 |
| 出典メモ | uspto-grants-1988_06 |