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Thiazole-5-carboxylic acid → N-(7-Chloro-1,8-naphthyridin-2-yl)-5-thiazolecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thiazole-5-carboxylic acid | HCID 84494 | — |
| 反応物 | 7-Chloro-1,8-naphthyridin-2-amine | HCID 85199 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-(7-Chloro-1,8-naphthyridin-2-yl)-5-thiazolecarboxamide | HCID 13983408 | 68% |
反応手順
The procedure is similar to that described in Example 2, but starting with 5-thiazolecarboxylic acid (4.5 g), N,N'-carbonyldiimidazole (6.8 g) and 2-amino-7-chloro-1,8-naphthyridine (5 g). The product obtained by precipitation in water is purified by recrystallization in a dimethylformamide/acetonitrile (5:5 by volume) mixture (120 cc). N-(7-Chloro-1,8-naphthyridin-2-yl)-5-thiazolecarboxamide (5.5 g), m.p. 292° C., is thereby obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04753941 |
| 出典データセット | uspto-grants-1988_06 |
| ORD ID | ord-8f0a3522ed364424b0f2c82f36caa01d |
| 出典メモ | uspto-grants-1988_06 |