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1-Methylpiperazine → 1-(5-Bromo-6-methylpyridin-2-yl)-4-methylpiperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methylpiperazine | HCID 53167 | — |
| 反応物 | 3-Bromo-6-chloro-2-methylpyridine | HCID 14866674 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(5-Bromo-6-methylpyridin-2-yl)-4-methylpiperazine | HCID 75487540 | — |
反応手順
A solution of 3-bromo-6-chloro-2-methylpyridine (700 mg, 3.39 mmol) and 1-methylpiperazine (0.753 mL, 6.78 mmol) in DMF (4 mL) was heated in microwave reactor at 150° C. for 50 minutes. The mixture was subsequently purified via preparative HPLC, eluting with a gradient of 10-70% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA) to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434743B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-06e1793c54df47aa974c0aa09112478d |
| 出典メモ | uspto-grants-2016_09 |