1-Methylpiperazine → 1-(5-Bromo-6-methylpyridin-2-yl)-4-methylpiperazine

HRID 58049

反応式

HRID 58049 の反応式
[Br:1][C:2]1[C:3]([CH3:9])=[N:4][C:5](Cl)=[CH:6][CH:7]=1.[CH3:10][N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:14]2[CH2:15][CH2:16][N:11]([CH3:10])[CH2:12][CH2:13]2)=[N:4][C:3]=1[CH3:9]

参加物

4

反応物 2

HCID 531671-MethylpiperazineHCID 148666743-Bromo-6-chloro-2-methylpyridine

生成物 1

HCID 754875401-(5-Bromo-6-methylpyridin-2-yl)-4-methylpiperazine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 3-bromo-6-chloro-2-methylpyridine (700 mg, 3.39 mmol) and 1-methylpiperazine (0.753 mL, 6.78 mmol) in DMF (4 mL) was heated in microwave reactor at 150° C. for 50 minutes. The mixture was subsequently purified via preparative HPLC, eluting with a gradient of 10-70% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA) to give the title compound.

後処理

  1. customThe mixture was subsequently purified via preparative HPLC
  2. washeluting with a gradient of 10-70% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA)

出典と根拠

ORDレコード
ord-06e1793c54df47aa974c0aa09112478d
出典データセット
uspto-grants-2016_09
特許番号
US09434743B2

関連ノート

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