Methyl 2-bromopropionate → HCID 14326200、化合物
反応式
[CH2:1]([NH2:4])[C:2]#[CH:3].Br[CH:6]([CH3:11])[C:7]([O:9][CH3:10])=[O:8].C(=O)(O)[O-].[Na+]>O>[CH2:1]([NH:4][CH:6]([CH3:11])[C:7]([O:9][CH3:10])=[O:8])[C:2]#[CH:3]参加物
5
反応条件
- 温度
- 80 °C
実験手順
Into a 250 ml round bottom flask are placed 26 g (0.47 mole) of propargylamine, 78.8 g (0.47 mole) of methyl 2-bromopropionate, and 39.7 g (0.47 mole) of sodium bicarbonate. The reaction mixture is heated at 80° C. overnight. It is cooled and poured into 200 ml of water. Extraction with ether provides 45 g of crude product which is further purified by vacuum distillation (94°-95°/3 mm) to give 25 g of desired product.
後処理
- customInto a 250 ml round bottom flask are placed
- temperatureIt is cooled
- extractionExtraction with ether
- customprovides 45 g of crude product which
- distillationis further purified by vacuum distillation (94°-95°/3 mm)
出典と根拠
- ORDレコード
- ord-1eb52b5292e24d0a924fb1dbea791c72
- 出典データセット
- uspto-grants-1988_06
- 特許番号
- US04753957
反応ノート
読み込み中…