Methylamine → 4-Methylamino-3-nitroquinoline
反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[CH3:15][NH2:16]>C(O)C>[CH3:15][NH:16][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13]参加物
4
実験手順
To a suspension of 2.0 g of 4-chloro-3-nitroquinoline in 20 ml of dry ethanol is added 15 ml of 30% methylamine in ethanol. The mixture is stirred at room temperature for 30 minutes and concentrated in vacuo. The residue is triturated with excess water. The resulting crystals are collected by filtration and washed repeatedly with water. The crystals are dried over phosphorus pentoxide in vacuo to afford 1.82 g (93%) of 4-methylamino-3-nitroquinoline.
後処理
- concentrationconcentrated in vacuo
- customThe residue is triturated with excess water
- filtrationThe resulting crystals are collected by filtration
- washwashed repeatedly with water
- dry with materialThe crystals are dried over phosphorus pentoxide in vacuo
出典と根拠
- ORDレコード
- ord-a0273dc5255247159c8d25faa317f8ae
- 出典データセット
- uspto-grants-1988_06
- 特許番号
- US04753951
反応ノート
読み込み中…