1,3-Dimethyl-5-ethoxycarbonylbarbituric acid → 1,3-Dimethyl-5-[4-(2-isopropyl-6-methylpyrimidin-4-yloxy)phenylcarbamoyl]barbituric acid

HRID 580538ノート

反応式

HRID 580538 の反応式
[CH3:1][N:2]1[C:9](=[O:10])[CH:8]([C:11]([O:13]CC)=O)[C:6](=[O:7])[N:5]([CH3:16])[C:3]1=[O:4].[CH:17]([C:20]1[N:25]=[C:24]([O:26][C:27]2[CH:33]=[CH:32][C:30]([NH2:31])=[CH:29][CH:28]=2)[CH:23]=[C:22]([CH3:34])[N:21]=1)([CH3:19])[CH3:18]>C1(C)C=CC=CC=1>[CH3:16][N:5]1[C:6](=[O:7])[CH:8]([C:11](=[O:13])[NH:31][C:30]2[CH:29]=[CH:28][C:27]([O:26][C:24]3[CH:23]=[C:22]([CH3:34])[N:21]=[C:20]([CH:17]([CH3:19])[CH3:18])[N:25]=3)=[CH:33][CH:32]=2)[C:9](=[O:10])[N:2]([CH3:1])[C:3]1=[O:4]

参加物

4

反応物 2

HCID 5937141,3-Dimethyl-5-ethoxycarbonylbarbituric acidHCID 20133966HCID 20133966、化合物

生成物 1

HCID 201339651,3-Dimethyl-5-[4-(2-isopropyl-6-methylpyrimidin-4-yloxy)phenylcarbamoyl]barbituric acid

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

3.0 g (0.013 mole) of 1,3-dimethyl-5-ethoxycarbonylbarbituric acid and 3.2 g (0.013 mole) of 4-(2-isopropyl-6-methylpyrimidin-4-yloxy)aniline are suspended in 30 ml of toluene and heated for 18 hours at reflux temperature in an inert gas atmosphere (nitrogen). After cooling, the precipitate is isolated by filtration, washed with alcohol and dried.

後処理

  1. temperatureheated for 18 hours
  2. temperatureat reflux temperature in an inert gas atmosphere (nitrogen)
  3. temperatureAfter cooling
  4. customthe precipitate is isolated by filtration
  5. washwashed with alcohol
  6. customdried

出典と根拠

ORDレコード
ord-974fd465a25540a196a510ec2c481ca6
出典データセット
uspto-grants-1988_06
特許番号
US04753940

反応ノート

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