Hydrochloric Acid → 5-Hydroxy-5-(1-methyl-2-pyrrolyl)-2,4,6-(1H,3H,5H)pyrimidinetrione

HRID 580550

反応式

HRID 580550 の反応式
O.[NH:2]1[C:10](=[O:11])[C:8](=[O:9])[C:6](=[O:7])[NH:5][C:3]1=[O:4].[CH3:12][N:13]1[CH:17]=[CH:16][CH:15]=[CH:14]1.Cl>C(O)C>[OH:9][C:8]1([C:14]2[N:13]([CH3:12])[CH:17]=[CH:16][CH:15]=2)[C:6](=[O:7])[NH:5][C:3](=[O:4])[NH:2][C:10]1=[O:11]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 73041-MethylpyrroleHCID 167232,4,5,6(1H,3H)-Pyrimidinetetrone, monohydrate

生成物 1

HCID 212712485-Hydroxy-5-(1-methyl-2-pyrrolyl)-2,4,6-(1H,3H,5H)pyrimidinetrione収率 65%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Alloxan hydrate (3.2 g., 0.02 mole) was dissolved in 50 ml. of ethanol by warming. 1-Methylpyrrole (1.6 g., 0.02 mole) was added and the mixture warmed for 5 minutes on a steam bath, while perfusing with hydrogen chloride. After standing at room temperature for 0.5 hour, the reaction mixture was evaporated to dryness and the residue triturated with water to yield title product as a solid [2.9 g.; m/e 223; Rf 0.5 (1:1 ethyl acetate:hexane/5% acetic acid)].

後処理

  1. temperaturethe mixture warmed for 5 minutes on a steam bath
  2. customthe reaction mixture was evaporated to dryness
  3. customthe residue triturated with water

出典と根拠

ORDレコード
ord-3b9bf827d1a24618ad85cf536806ac10
出典データセット
uspto-grants-1988_06
特許番号
US04753956

関連ノート

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