Hydrochloric Acid → 7-(3-Amino-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride

HRID 580577ノート

反応式

HRID 580577 の反応式
C(OC([NH:8][CH:9]1[CH:13]([CH3:14])[CH2:12][N:11]([C:15]2[C:24]([F:25])=[C:23]3[C:18]([C:19](=[O:32])[C:20]([C:29]([OH:31])=[O:30])=[CH:21][N:22]3[CH:26]3[CH2:28][CH2:27]3)=[CH:17][C:16]=2[F:33])[CH2:10]1)=O)(C)(C)C.[ClH:34]>CO>[ClH:34].[NH2:8][CH:9]1[CH:13]([CH3:14])[CH2:12][N:11]([C:15]2[C:24]([F:25])=[C:23]3[C:18]([C:19](=[O:32])[C:20]([C:29]([OH:31])=[O:30])=[CH:21][N:22]3[CH:26]3[CH2:28][CH2:27]3)=[CH:17][C:16]=2[F:33])[CH2:10]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 139331017-(3-t-Butoxycarbonylamino-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

生成物 1

HCID 139205727-(3-Amino-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

7-(3-t-Butoxycarbonylamino-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (0.27 g) was dissolved in a mixture of methanol (5 ml) and concentrated hydrochloric acid (5 ml) and stirred at room temperature for 30 minutes. After the reacting mixture was concentrated under reduced pressure, the resulting residue was dissolved in ethanol (10 ml) and crystallized with cooling. The resulting precipitate was recrystallized from methanol to give the title compound (0.14 g) as pale yellow powder, mp 272°-274° C.

後処理

  1. concentrationAfter the reacting mixture was concentrated under reduced pressure
  2. dissolutionthe resulting residue was dissolved in ethanol (10 ml)
  3. customcrystallized
  4. temperaturewith cooling
  5. customThe resulting precipitate was recrystallized from methanol

出典と根拠

ORDレコード
ord-e9e3f3ea12494c86975d71e914709420
出典データセット
uspto-grants-1988_06
特許番号
US04753953

反応ノート

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