Hydrochloric Acid → (3S)-10-(cis-3-Amino-4-methyl-1-pyrrolidinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid hydrochloride

HRID 580595ノート

反応式

HRID 580595 の反応式
C(OC([NH:8][C@H:9]1[C@@H:13]([CH3:14])[CH2:12][N:11]([C:15]2[C:16]([F:33])=[CH:17][C:18]3[C:28](=[O:29])[C:27]([C:30]([OH:32])=[O:31])=[CH:26][N:20]4[C@@H:21]([CH3:25])[CH2:22][O:23][C:24]=2[C:19]=34)[CH2:10]1)=O)(C)(C)C.[ClH:34]>C(O)C>[ClH:34].[NH2:8][C@H:9]1[C@@H:13]([CH3:14])[CH2:12][N:11]([C:15]2[C:16]([F:33])=[CH:17][C:18]3[C:28](=[O:29])[C:27]([C:30]([OH:32])=[O:31])=[CH:26][N:20]4[C@@H:21]([CH3:25])[CH2:22][O:23][C:24]=2[C:19]=34)[CH2:10]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 70419344(3S)-10-(cis-3-t-Butoxycarbonylamino-4-methyl-1-pyrrolidinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid

生成物 1

HCID 67308365(3S)-10-(cis-3-Amino-4-methyl-1-pyrrolidinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of (3S)-10-(cis-3-t-butoxycarbonylamino-4-methyl-1-pyrrolidinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid (0.6 g) in ethanol (8 ml) and ethanolic hydrochloride solution (10 ml) was stirred for 1.5 hours at room temperature and then concentrated. To the residue was added ethanol and the resulting precipitate was collected by filtration to give the title compound (0.44 g) as yellowish powder, mp 285° C. (decompd.).

後処理

  1. concentrationconcentrated
  2. additionTo the residue was added ethanol
  3. filtrationthe resulting precipitate was collected by filtration

出典と根拠

ORDレコード
ord-1590dd5fbb4340a0878cc56ed05042bb
出典データセット
uspto-grants-1988_06
特許番号
US04753953

反応ノート

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