1,2-Dichloroethane → 4-bromo-N-(2-hydroxyethyl)picolinamide

関与物質

役割	名称	HCID	仕込み量
反応物	1,2-Dichloroethane	HCID 11	—
反応物	Ethanolamine	HCID 700	—
反応物	1-Hydroxybenzotriazole	HCID 75771	—
反応物	Diisopropylethylamine	HCID 81531	—
反応物	4-Bromopyridine-2-carboxylic acid	HCID 735150	—
溶媒	Dimethylformamide	HCID 6228	—
溶媒	Dichloromethane	HCID 6344	—
生成物	4-bromo-N-(2-hydroxyethyl)picolinamide	HCID 89781740	—

反応手順

To 4-bromopicolinic acid (0.3 g, 1.485 mmol) in DMF (4 mL) were added 2-aminoethanol (0.181 g, 2.97 mmol), HOBt (0.301 g, 2.228 mmol), and EDC (0.456 g, 2.376 mmol), followed by N-ethyl-N-isopropylpropan-2-amine (1.293 mL, 7.43 mmol). The reaction mixture was stirred for 18 hours at room temperature. The reaction mixture was diluted with DCM, washed with brine, and concentrated to give the title compound, which was used without further purification.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09434743B2
出典データセット	uspto-grants-2016_09
ORD ID	ord-7c297db1e83246e1a0f83a2fd9b37419
出典メモ	uspto-grants-2016_09