1,2-Dichloroethane → 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxamide

関与物質

役割	名称	HCID	仕込み量
反応物	1,2-Dichloroethane	HCID 11	—
反応物	Ammonium Chloride	HCID 25517	—
反応物	1-Hydroxybenzotriazole	HCID 75771	—
反応物	Diisopropylethylamine	HCID 81531	—
反応物	4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid	HCID 2779833	—
溶媒	Dimethylformamide	HCID 6228	—
溶媒	Ethyl Acetate	HCID 8857	—
生成物	4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxamide	HCID 4766142	—

反応手順

To 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid (0.3 g, 1.370 mmol) in DMF (5 mL) were added ammonium chloride (0.293 g, 5.48 mmol), HOBt (0.222 g, 1.644 mmol), and EDC (0.368 g, 1.917 mmol), followed by N-ethyl-N-isopropylpropan-2-amine (1.193 mL, 6.85 mmol). The reaction mixture was stirred for 18 hours at room temperature. The reaction mixture was subsequently diluted with EtOAc, washed with brine, dried over Na2SO4, and concentrated to give the title compound, which was used without further purification (0.28 g).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09434743B2
出典データセット	uspto-grants-2016_09
ORD ID	ord-cc234f99af78493bbb90bc9a27ab3330
出典メモ	uspto-grants-2016_09