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HRID 58064作成日：2026年10月25日
4-Bromo-6-(trifluoromethyl)-1H-indazole → methyl 3-fluoro-4-(6-(trifluoromethyl)-1H-indazol-4-yl)benzoate
https://huagongshe.com/reaction/58064
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Bromo-6-(trifluoromethyl)-1H-indazole | HCID 24729232 | — |
| 反応物 | 2-Fluoro-4-(methoxycarbonyl)benzeneboronic acid | HCID 24824345 | — |
| 触媒 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 溶媒 | Sodium Bicarbonate | HCID 516892 | — |
| 生成物 | methyl 3-fluoro-4-(6-(trifluoromethyl)-1H-indazol-4-yl)benzoate | HCID 89783142 | — |
反応手順
A vial was charged with a mixture of 4-bromo-6-(trifluoromethyl)-1H-indazole (0.402 g, 1.515 mmol), (2-fluoro-4-(methoxycarbonyl)phenyl)boronic acid (0.3 g, 1.515 mmol) and PdCl2(dppf) (0.055 g, 0.076 mmol) in dioxane (10 mL) and aqueous saturated NaHCO3 (3 mL). The resulting light yellow suspension was heated at 140° C. for 45 minutes in a microwave reactor. The reaction mixture was subsequently concentrated. The crude residue was diluted with EtOAc and washed with water, dried over Na2SO4, and the volatiles were removed via rotary evaporation to give the title compound, which was used without further purification (0.4 g, 78%). ESI-MS m/z [M+H]+ calc'd for C16H10F4N2O2, 339.1. found 339.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09434743B2 |
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| 出典データセット | uspto-grants-2016_09 |
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| ORD ID | ord-d3a1dd7dfe19445db35b6d513b26417e |
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| 出典メモ | uspto-grants-2016_09 |
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