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Ammonia → 5,6,7,8-Tetrahydro-2-phenyl-3-(benzoylaminoiminomethyl)imidazo[2,1-b]benzothiazole

HRID 580926
ノート
印刷プレビュー

反応式

HRID 580926 の反応式
[C:1]1([C:7]2[N:8]=[C:9]3[N:13]([C:14]=2[CH:15]=O)[C:12]2[CH2:17][CH2:18][CH2:19][CH2:20][C:11]=2[S:10]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:21]([NH:29][NH2:30])(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.Cl.C(O)C.N>O>[C:1]1([C:7]2[N:8]=[C:9]3[N:13]([C:14]=2[CH:15]=[N:30][NH:29][C:21](=[O:28])[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:12]2[CH2:17][CH2:18][CH2:19][CH2:20][C:11]=2[S:10]3)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 222AmmoniaHCID 11955BenzoylhydrazineHCID 107316142-Phenyl-4,5,6,7,8-pentahydroimidazo[2,1-b]benzothiazole-3-carbaldehydeHCID 21887872Ethanol hydrochloride

生成物 1

HCID 23145105,6,7,8-Tetrahydro-2-phenyl-3-(benzoylaminoiminomethyl)imidazo[2,1-b]benzothiazole収率 84%

試薬・触媒・溶媒 1

HCID 962
Water
溶媒

実験手順

0.28 g of 5,6,7,8-tetrahydro-2-phenyl-3-formylimidazo[2,1-b]benzothiazole and 0.15 g of benzohydrazide were stirred over night in 20 ml of a 0.1N hydrochloric acid-ethanol solution at room temperature and the precipitated crystal obtained by filtration. The crystals were dissolved in water and the solution was made alkaline by ammonia solution, then extracted by chloroform. The extract was washed with water and dried, then the solvent was distilled off and the residue was crystallized from ethyl acetate to obtain the desired substance in an amount of 0.35 g (yield of 84.0%).

後処理

  1. customthe precipitated crystal obtained by filtration
  2. extractionextracted by chloroform
  3. washThe extract was washed with water
  4. customdried
  5. distillationthe solvent was distilled off
  6. customthe residue was crystallized from ethyl acetate
  7. customto obtain the desired substance in an amount of 0.35 g (yield of 84.0%)

出典と根拠

ORDレコード
ord-6b09b8036967419295bf960b4f73ea62
出典データセット
uspto-grants-1999_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05919799

反応ノート

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