Triethylamine → (R)-3-benzylpiperazin-2-one

HRID 581194ノート

反応式

HRID 581194 の反応式
C[O:2][C:3](=O)[C@H:4]([NH:12][CH2:13][CH2:14][NH2:15])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C(N(CC)CC)C>C(Cl)Cl>[CH2:5]([C@H:4]1[NH:12][CH2:13][CH2:14][NH:15][C:3]1=[O:2])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 8471TriethylamineHCID 54002275(2R)-2-(2-aminoethylamino)-3-phenylpropionic acid methyl ester

生成物 1

HCID 16740989(R)-3-benzylpiperazin-2-one収率 63.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(2R)-2-(2-Aminoethylamino)-3-phenylpropionic acid methyl ester (0.67 g; 1.49 mmol) and triethylamine (1 ml) were dissolved in methylene chloride (10 ml) and stirred for 48 hours at room temperature. The reaction mixture was evaporated and the residue was chromatographed on silica (2.5×30 cm) using a 7% solution of ammonia in ethanol/methylene chloride (1:9) as eluent to afford 0.18 g of (3R)-3-benzylpiperazin-2-one.

後処理

  1. customThe reaction mixture was evaporated
  2. customthe residue was chromatographed on silica (2.5×30 cm)

出典と根拠

ORDレコード
ord-fcd0501296b94eeb9008f2a96e14f9e4
出典データセット
uspto-grants-1999_07
特許番号
US05919777

反応ノート

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