Acetic Anhydride → N-(3,5-dimethoxyphenyl)acetamide
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:11])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>C1(C)C=CC=CC=1>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([NH:11][C:12](=[O:14])[CH3:13])[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1参加物
4
実験手順
To a solution of 3,5-dimethoxy-phenylamine (20 g, 0.131 mol) in toluene (110 mL) was added acetic anhydride (14 g, 0.137 mmol) at room temperature. The resulting mixture was stirred for 18 hours at room temperature. PE (55 mL) was added, the precipitate was filtered and washed with PE (100 mL) to obtain the title compound (24.2 g, yield: 95%). 1H-NMR (400 MHz, CDCl3) δ 2.16 (s, 3H), 3.77 (s, 6H), 6.23 (s, 1H), 6.75 (s, 2H), 7.20 (s, 1H).
後処理
- additionPE (55 mL) was added
- filtrationthe precipitate was filtered
- washwashed with PE (100 mL)
出典と根拠
- ORDレコード
- ord-7e9f9581dfb944339b040643ad69ba60
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434697B2
反応ノート
読み込み中…