Acetic Anhydride → N-(3,5-dimethoxyphenyl)acetamide

HRID 58123

反応式

HRID 58123 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:11])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>C1(C)C=CC=CC=1>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([NH:11][C:12](=[O:14])[CH3:13])[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 663013,5-Dimethoxyaniline

生成物 1

HCID 702039N-(3,5-dimethoxyphenyl)acetamide収率 90,486%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of 3,5-dimethoxy-phenylamine (20 g, 0.131 mol) in toluene (110 mL) was added acetic anhydride (14 g, 0.137 mmol) at room temperature. The resulting mixture was stirred for 18 hours at room temperature. PE (55 mL) was added, the precipitate was filtered and washed with PE (100 mL) to obtain the title compound (24.2 g, yield: 95%). 1H-NMR (400 MHz, CDCl3) δ 2.16 (s, 3H), 3.77 (s, 6H), 6.23 (s, 1H), 6.75 (s, 2H), 7.20 (s, 1H).

後処理

  1. additionPE (55 mL) was added
  2. filtrationthe precipitate was filtered
  3. washwashed with PE (100 mL)

出典と根拠

ORDレコード
ord-7e9f9581dfb944339b040643ad69ba60
出典データセット
uspto-grants-2016_09
特許番号
US09434697B2

関連ノート

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