N-[3-(1-Methylpiperidin-4-YL)-1H-pyrrolo[3,2-B]pyridin-5-YL]acetamide → 3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine

HRID 581236

反応式

HRID 581236 の反応式
C([NH:4][C:5]1[N:10]=[C:9]2[C:11]([CH:14]3[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]3)=[CH:12][NH:13][C:8]2=[CH:7][CH:6]=1)(=O)C>Cl>[NH2:4][C:5]1[N:10]=[C:9]2[C:11]([CH:14]3[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]3)=[CH:12][NH:13][C:8]2=[CH:7][CH:6]=1

参加物

3

反応物 1

HCID 10445946N-[3-(1-Methylpiperidin-4-YL)-1H-pyrrolo[3,2-B]pyridin-5-YL]acetamide

生成物 1

HCID 102202303-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine収率 93.4%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A mixture of 2.5 gm (9.2 mMol) 5-(N-acetylamino)-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine in 40 mL 2N hydrochloric acid was heated at reflux for 1 hour. The reaction mixture was cooled to room temperature, concentrated under reduced pressure, basified (pH ~11) with 2N aqueous sodium hydroxide, concentrated under reduced pressure, and extracted well with 3:1 chloroform:isopropanol. The organic extracts were combined, dried over magnesium sulfate and concentrated under reduced pressure to provide 1.98 gm (93%) of the title compound as a brown solid.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 1 hour
  3. concentrationconcentrated under reduced pressure
  4. concentrationconcentrated under reduced pressure
  5. extractionextracted well with 3:1 chloroform
  6. dry with materialdried over magnesium sulfate
  7. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-d7b98b85d42b470b973b3fbabcce8020
出典データセット
uspto-grants-1999_07
特許番号
US05919936

関連ノート

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