関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylamine | HCID 674 | — |
| 反応物 | methyl 2-(N-tert-butylsulfamoyl)-4-nitrobenzoate | HCID 15240542 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N-tert.-butyl-2-dimethylaminocarbonyl-5-nitro-benzenesulfonamide | HCID 15240543 | 76.8% |
反応手順
115 g of N-tert.-butyl-2-methoxycarbonyl-5-nitro-benzenesulfonamide (Example c) in 1500 ml of methanol are gassed with about 200 g of dimethylamine. The mixture is stirred at about 35° C. for one week. The solution is concentrated under reduced pressure, the residue is taken up in ethyl acetate and the mixture is washed successively with dilute hydrochloric acid, saturated NaHCO3 solution and saturated NaCl solution. After drying over MgSO4, the organic phase is concentrated. 92 g of N-tert.-butyl-2-dimethylaminocarbonyl-5-nitro-benzensulfonamide are obtained: m.p.: 138-141° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05922646 |
|---|
| 出典データセット | uspto-grants-1999_07 |
|---|
| ORD ID | ord-acded5627ff04c47b809c9982851e0f7 |
|---|
| 出典メモ | uspto-grants-1999_07 |
|---|
