関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | [2-(3-Fluoro-4-nitro-phenyl)-vinyl]-dimethyl-amine | HCID 91252016 | 63% |
反応手順
A mixture of 2-fluoro-4-methyl-1-nitro-benzene (3 g, 19.3 mmol), N,N-dimethylformamide dimethylacetal (10 mL) and 3 mL of DMF (30 mL) was heated at 125° C. for 1 hour. The mixture was cooled and concentrated under reduced pressure to give a purple solid. Trituration with hexanes gave the pure title product (2.5 g, yield: 63%). MS (ESI): 211 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09434697B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-817877ea94764f208294308ee7121a8b |
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| 出典メモ | uspto-grants-2016_09 |
|---|
