関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonia hydroxide | HCID 21862953 | — |
| 反応物 | [2-(3-Fluoro-4-nitro-phenyl)-ethyl]-dimethyl-amine | HCID 118024700 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | HCID 118024526 | HCID 118024526 | 55% |
反応手順
To a solution of [2-(3-fluoro-4-nitro-phenyl)-ethyl]-dimethyl-amine (800 g, 3.76 mmol) in MeOH (20 mL) was added ammonia hydroxide (5 mL). The reaction mixture was heated at 100° C. under microwave heating for 1.5 hours. The resulting yellow solid was collected and washed with water, dried under vacuum and combined with a previous batch to give the pure title compound (560 mg, yield: 55%). MS (ESI): 210 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09434697B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-0d6f805db90f42b1a9f8c164f28747a3 |
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| 出典メモ | uspto-grants-2016_09 |
|---|
