Acetic Anhydride → N-(3,5-dimethoxyphenyl)acetamide

HRID 58174

反応式

HRID 58174 の反応式
[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH3:8][O:9][C:10]1[CH:11]=[C:12]([CH:14]=[C:15]([O:17][CH3:18])[CH:16]=1)[NH2:13]>C1(C)C=CC=CC=1.CCCCCC>[CH3:18][O:17][C:15]1[CH:14]=[C:12]([NH:13][C:1](=[O:3])[CH3:2])[CH:11]=[C:10]([O:9][CH3:8])[CH:16]=1

参加物

5

反応物 2

HCID 7918Acetic AnhydrideHCID 663013,5-Dimethoxyaniline

生成物 1

HCID 702039N-(3,5-dimethoxyphenyl)acetamide収率 98%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 8058Hexane溶媒

実験手順

Acetic anhydride (6.5 mL) was added slowly to a stirred solution of 3,5-dimethoxy aniline (10 g, 65.359 mmol) in toluene (50 mL) under argon atmosphere at room temperature and resulting reaction mixture was stirred for 15 h. After completion of the reaction, reaction was diluted with Hexane and resulted precipitate was collected by filtration and dried under vacuum to afford the title compound (12.5 g, 98% of yield) as a off-white solid. 1HNMR (CDCl3, 300 MHz): δ 7.38 (s, 1H), 6.75 (d, 2H), 6.23 (s, 1H), 3.76 (s, 6H), 2.15 (s, 3H); MS (ESI): 196.1 [M+H]+.

後処理

  1. customresulting
  2. customreaction mixture
  3. customAfter completion of the reaction, reaction
  4. customresulted precipitate
  5. filtrationwas collected by filtration
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-135f662ea86f44bab12e31be80d689b7
出典データセット
uspto-grants-2016_09
特許番号
US09434697B2

関連ノート

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