Benzoyl chloride, 3-nitro- → 3-Nitro-N-(3-pyridinylmethyl)benzamide

HRID 581754ノート

反応式

HRID 581754 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7](Cl)=[O:8])([O-:3])=[O:2].C(=O)(O)[O-].[Na+].[NH2:18][CH2:19][C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1>C(OCC)C>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([NH:18][CH2:19][C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1)=[O:8])([O-:3])=[O:2]

参加物

5

反応物 3

HCID 8495Benzoyl chloride, 3-nitro-HCID 310183-PyridinemethanamineHCID 516892Sodium Bicarbonate

生成物 1

HCID 7434213-Nitro-N-(3-pyridinylmethyl)benzamide収率 46%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a stirred two-phase solution of 3-nitrobenzoyl chloride (9.3 g) in a mixture of diethyl ether (50 ml) and saturated sodium bicarbonate solution (50 ml) was added 3-aminomethylpyridine (5.4 g) in an ice-cooled bath. The mixture was stirred vigorously at ambient temperature for 30 minutes. The reaction mixture was filtered, and the resulting solid was washed with water. The solid was further solidified with diisopropyl alcohol-water to afford 3-nitro-N-(3-pyridylmethyl)benzamide (5.91 g) as a pale yellow amorphous solid.

後処理

  1. temperaturecooled bath
  2. filtrationThe reaction mixture was filtered
  3. washthe resulting solid was washed with water

出典と根拠

ORDレコード
ord-f2eed9f4507345e593682fd9efd7097f
出典データセット
uspto-grants-1999_07
特許番号
US05922711

反応ノート

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