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Ethyl bromoacetate → ethyl N-(4-fluorophenyl)glycine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl bromoacetate | HCID 7748 | — |
| 反応物 | 4-Fluoroaniline | HCID 9731 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 18-Crown-6 | HCID 28557 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | ethyl N-(4-fluorophenyl)glycine | HCID 61998283 | — |
反応手順
4-Fluoroaniline (5 g), potassium carbonate (3.11 g) and a catalytic amount of 18-Crown-6 were stirred together in 50 ml of ethanol. A solution of ethylbromoacetate (7.52 g) in 25 ml of ethanol was added dropwise and the reaction was heated to reflux.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05246933 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-d5edec4fc25d4165a206856d008fcc0a |
| 出典メモ | uspto-grants-1993_09 |