6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-1H-pyrimidine-2,4-dione → 1-{[3,4-Di(hydroxymethyl)cyclopent-1-en-1-yl]methyl}-5-ethyl-6-(3,5-di-methylphenylthio)-2,4-pyrimidinedione

HRID 581873

反応式

HRID 581873 の反応式
[CH2:1]([C:3]1[C:4](=[O:19])[NH:5][C:6](=[O:18])[NH:7][C:8]=1[S:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].[Si]([O:27][CH2:28][CH:29]1[CH:33]([CH2:34][O:35][Si](C(C)(C)C)(C)C)[CH2:32][C:31]([CH2:43]Br)=[CH:30]1)(C(C)(C)C)(C)C>>[OH:27][CH2:28][CH:29]1[CH:33]([CH2:34][OH:35])[CH2:32][C:31]([CH2:43][N:7]2[C:8]([S:9][C:10]3[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=3)=[C:3]([CH2:1][CH3:2])[C:4](=[O:19])[NH:5][C:6]2=[O:18])=[CH:30]1

参加物

3

反応物 2

HCID 104927276-(3,5-dimethylphenyl)sulfanyl-5-ethyl-1H-pyrimidine-2,4-dioneHCID 54350482[3,4-Di(t-butyldimethylsilyloxymethyl)cyclopent-1-en-1-yl]methyl bromide

生成物 1

HCID 570656861-{[3,4-Di(hydroxymethyl)cyclopent-1-en-1-yl]methyl}-5-ethyl-6-(3,5-di-methylphenylthio)-2,4-pyrimidinedione収率 19.3%

実験手順

5-Ethyl-6-(3,5-dimethylphenylthio)-2,4-pyrimidinedione and [3,4-di(t-butyldimethylsilyloxymethyl)cyclopent-1-en-1-yl]methyl bromide were reacted by the same method with example 28 to obtain the titled compound (53 mg).

出典と根拠

ORDレコード
ord-b0ba63a240664750aec8037d1484c263
出典データセット
uspto-grants-1999_07
特許番号
US05922727

関連ノート

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