関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Bromoaniline | HCID 11562 | — |
| 反応物 | Isopropyl 4-chloro-3-nitrobenzoate | HCID 693119 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | Isopropyl 4-(3-bromophenylamino)-3-nitrobenzoate | HCID 54019765 | 65% |
反応手順
A mixture of i-propyl 4-chloro-3-nitrobenzoate (25.88 g, 0.11 mol), 3-bromoaniline (17.36 ml, 0.16 mol) and potassium carbonate (14.63 g, 0.11 mol) in N-methyl-2-pyrrolidone (25 ml) is heated to 150° C. for 3 days. After cooling the mixture is poured into diluted hydrochloric acid (300 ml, 1 M). The precipitate is filtered off, washed with water and dried (37.4 g). This crude product is washed with hot 2-propanol to afford pure 24 (26.25 g, 65%). Mp 162-165° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05922725 |
|---|
| 出典データセット | uspto-grants-1999_07 |
|---|
| ORD ID | ord-51be9a7f15b1460d834432182bba1ba0 |
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| 出典メモ | uspto-grants-1999_07 |
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