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Isopropanol → (1-(5-hydroxymethylfur-2-ylmethyl)-1H-benzoimidazole-2-yl)(piperidin-4-yl)amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | (1-(5-hydroxymethylfur-2-ylmethyl)-1H-benzimidazol-2-yl)(1-ethoxycarbonylpiperidin-4-yl)amine | HCID 22009043 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (1-(5-hydroxymethylfur-2-ylmethyl)-1H-benzoimidazole-2-yl)(piperidin-4-yl)amine | HCID 22009201 | — |
反応手順
Combine (1-(5-hydroxymethylfur-2-ylmethyl)-1H-benzimidazol-2-yl)(1-ethoxycarbonylpiperidin-4-yl)amine (1 mmol), potassium hydroxide (1.2 mmcl), and isopropanol (20 mL). Heat to reflux. After 18 hours, evaporate intcacuo to give a residue. Combine the resczue and water. Extract with dichloromethane. Dry the organic layer over MgSO4, filter, and evaporate in vacuo to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05922737 |
| 出典データセット | uspto-grants-1999_07 |
| ORD ID | ord-d21f8daaa0be4e20a557898196d14481 |
| 出典メモ | uspto-grants-1999_07 |