Bromine → 3-(3-Bromo-4-methoxyphenyl)propanoic acid

HRID 582202

反応式

HRID 582202 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:5][CH:4]=1.[Br:14]Br>C(O)(=O)C.O>[Br:14][C:8]1[CH:7]=[C:6]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:4][C:3]=1[O:2][CH3:1]

参加物

5

反応物 2

HCID 24408BromineHCID 957503-(p-Methoxyphenyl)propionic acid

生成物 1

HCID 45476083-(3-Bromo-4-methoxyphenyl)propanoic acid収率 87%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

実験手順

To a solution of 3-(4-methoxyphenyl)propionic acid (4.0 g, 22.2 mmol) in acetic acid (20 ml) was added bromine (3.9 g, 24.4 mmol) gradually dropwise at 10° C. and the mixture was stirred at room temperature for 30 minutes. This reaction mixture was diluted with water and extracted with ethyl acetate. The extract was washed serially with saturated saline and water and dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. The residue was washed with hexane to provide the title compound (yield 5.0 g, 87%).

後処理

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed serially with saturated saline and water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure
  5. washThe residue was washed with hexane

出典と根拠

ORDレコード
ord-5ecfdcfbe9494c28b0be488c71647880
出典データセット
uspto-grants-1999_07
特許番号
US05922771

関連ノート

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