HCID 383402、化合物 → HCID 12670450、化合物

HRID 582206ノート

反応式

HRID 582206 の反応式
[CH:1](=[C:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([O:17][CH3:18])=[CH:13][CH:14]=2)[C:9]1=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>C(O)C.[C].[Pd]>[CH2:1]([CH:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([O:17][CH3:18])=[CH:13][CH:14]=2)[C:9]1=[O:19])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 383402HCID 383402、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 12670450HCID 12670450、化合物収率 92%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

To a solution of 2-benzylidene-6-methoxy-1-indanone (12.25 g, 48.9 mmol) in ethanol (500 ml) was added 10% hydrous palladium-carbon (1.5 g) and catalytic reduction was carried out in a hydrogen stream at atmospheric temperature and pressure. The palladium-carbon was then filtered off and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate-hexane=2:8) to provide the title compound (yield 11.26 g, 92%; oil).

後処理

  1. filtrationThe palladium-carbon was then filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography (ethyl acetate-hexane=2:8)

出典と根拠

ORDレコード
ord-5bbaac9310c343f9b16c82369d772438
出典データセット
uspto-grants-1999_07
特許番号
US05922771

反応ノート

読み込み中…