Water → 3-(3-Fluoro-4-methoxyphenyl)propionic acid

HRID 582208ノート

反応式

HRID 582208 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][C:12]([O:14]CC)=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].O.[OH-].[K+]>C(O)C.Cl>[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

参加物

6

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 22558762HCID 22558762、化合物

生成物 1

HCID 30179663-(3-Fluoro-4-methoxyphenyl)propionic acid収率 96%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

To a solution of ethyl 3-(3-fluoro-4-methoxyphenyl)propionate (29.1 g, 129 mmol) in ethanol(50 ml)-water(50 ml) was added potassium hydroxide (9.4 g, 167 mmol) and the mixture was stirred at 80° C. for 1 hour. After cooling, the reaction mixture was poured in diluted hydrochloric acid and the resulting crystals were recovered by filtration and washed with diethyl ether to provide the title compound (yield 24.4 g, 96%).

後処理

  1. temperatureAfter cooling
  2. filtrationthe resulting crystals were recovered by filtration
  3. washwashed with diethyl ether

出典と根拠

ORDレコード
ord-092c0705c8a040189f7bc12497739e4b
出典データセット
uspto-grants-1999_07
特許番号
US05922771

反応ノート

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