関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Gamma-Butyrolactone | HCID 7302 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 2-(Aminomethyl)-2-methyl-1,3-propanediamine | HCID 4526530 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-(Aminomethyl)-3-methyl-2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidine | HCID 18407487 | — |
反応手順
A mixture of 21.03 g (0.24 mol) of γ-butyrolactone and 1.31 g (24 mmol) of ammonium chloride in 114.5 g (0.98 mol) of 1,1,1-tris(aminomethyl)ethane was heated at 250° C. in an autoclave. After 1.5 h, the mixture was cooled and the excess amine and the water formed were removed by distillation. The residue was distilled at 200°-240° C./18 mbar. The yield was 22.0 g (54%) of yellowish oil. The boiling point was 117°-120° C./1 mbar. Other data concerning the product was:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05922869 |
|---|
| 出典データセット | uspto-grants-1999_07 |
|---|
| ORD ID | ord-f49b413a46ca404798e127f578a48423 |
|---|
| 出典メモ | uspto-grants-1999_07 |
|---|
